Allogeneic TransplantationAllogeneic transplants use another person’s haematopoietic progenitor cells and are more complex than autologous procedures.
The donor's stem cells must match the genetic make-up of the recipients cells as closely as possible. Blood tests called tissue typing, are done to work out if the donor cells match.
The most suitable donor is usually a brother or a sister, there is a 25 -30% chance that a patient will have a sibling whose stem cells match. If there is not a match in the family, then a search is made of the Australian Bone Marrow Donor Registry (ABMDR) to look for a donor.
The allogeneic transplant is tailored to suit the patient and the disease they are being treated for. It can include high dose chemotherapy with or without radiotherapy, this is called a myeloablative transplant, or lower dose chemotherapy, called a reduced intensity or non-myeloablative transplant. Most patients spend a period of 3 - 6 weeks in hospital. |
